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Search Results for " histone demethylase "

20

Compounds

Cat No. Product Name Synonyms Targets
T16435 PBIT Histone Demethylase , Histone Methyltransferase
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (J...
T9243 PFI-90 Histone Demethylase , Others
PFI-90, a selective histone demethylase (KDM3B) inhibitor, targets PAX3-FOXO1 action and demonstrates potential antitumor activity. It induces apoptosis and myogenic differentiation, leading to increased cell death.
T15649 KDM5-IN-1 Histone Demethylase
KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.
T4214 KDM4D-IN-1 Histone Demethylase
KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).
T6847 GSK-J1 GSK J1 Histone Demethylase
GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, >10-fold selectivity over other tested demethylases.
T3677 GSK2879552 GSK2879552 2HCl Histone Demethylase
GSK2879552 is a selective, orally bioavailable, irreversible, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor, with potential antineoplastic activity.
T6545 IOX1 Histone Demethylase
IOX1 is the most effective broad-spectrum 2OG oxygenases(including the JmjC demethylases) inhibitor. The IC50 of IOX1 for KDM4A, KDM3A, is 0.6 and 0.1 uM, respectively.
T3100 GSK-J4 GSK J4 HCl Apoptosis , Histone Demethylase
GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX wit...
T3719 Daminozide Succinic Acid,DMASA,Aminozide Histone Demethylase
Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.
T3552 CPI-455 CPI-455 HCl Histone Demethylase
CPI-455 is a specific KDM5 inhibitor.
T13055 T-3775440 hydrochloride Histone Demethylase
T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).
T15648 KDM5-C70 Histone Demethylase
KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, inducing a genome-wide e...
T5484 GSK467 Histone Demethylase , Histone Methyltransferase
GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).
TQ0050 NCGC00244536 KDM4B Inhibitor B3 Histone Demethylase
NCGC00244536 (KDM4B Inhibitor B3) is a potent KDM4B inhibitor (IC50: 10 nM).
T2304 SP2509 HCI-2509 Apoptosis , Histone Demethylase
SP2509 is a specific histone demethylase LSD1 inhibitor(IC50 =13 nM).
T4527 Seclidemstat SP-2577 Histone Demethylase
Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.
T4100 AS8351 NSC51355,AS-8351,AS 8351 Histone Demethylase
AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblas...
T5368 Eicosapentaenoic Acid Histone Demethylase , Others , Endogenous Metabolite
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms.
T6593 ML324 Histone Demethylase , Others , HSV
ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).
T5825 Iadademstat dihydrochloride ORY-1001(trans) Histone Demethylase
Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia.
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