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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16435 | PBIT | Histone Demethylase , Histone Methyltransferase | |
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (J... | |||
T9243 | PFI-90 | Histone Demethylase , Others | |
PFI-90, a selective histone demethylase (KDM3B) inhibitor, targets PAX3-FOXO1 action and demonstrates potential antitumor activity. It induces apoptosis and myogenic differentiation, leading to increased cell death. | |||
T15649 | KDM5-IN-1 | Histone Demethylase | |
KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM. | |||
T4214 | KDM4D-IN-1 | Histone Demethylase | |
KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM). | |||
T6847 | GSK-J1 | GSK J1 | Histone Demethylase |
GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, >10-fold selectivity over other tested demethylases. | |||
T3677 | GSK2879552 | GSK2879552 2HCl | Histone Demethylase |
GSK2879552 is a selective, orally bioavailable, irreversible, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor, with potential antineoplastic activity. | |||
T6545 | IOX1 | Histone Demethylase | |
IOX1 is the most effective broad-spectrum 2OG oxygenases(including the JmjC demethylases) inhibitor. The IC50 of IOX1 for KDM4A, KDM3A, is 0.6 and 0.1 uM, respectively. | |||
T3100 | GSK-J4 | GSK J4 HCl | Apoptosis , Histone Demethylase |
GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX wit... | |||
T3719 | Daminozide | Succinic Acid,DMASA,Aminozide | Histone Demethylase |
Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily. | |||
T3552 | CPI-455 | CPI-455 HCl | Histone Demethylase |
CPI-455 is a specific KDM5 inhibitor. | |||
T13055 | T-3775440 hydrochloride | Histone Demethylase | |
T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM). | |||
T15648 | KDM5-C70 | Histone Demethylase | |
KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, inducing a genome-wide e... | |||
T5484 | GSK467 | Histone Demethylase , Histone Methyltransferase | |
GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM). | |||
TQ0050 | NCGC00244536 | KDM4B Inhibitor B3 | Histone Demethylase |
NCGC00244536 (KDM4B Inhibitor B3) is a potent KDM4B inhibitor (IC50: 10 nM). | |||
T2304 | SP2509 | HCI-2509 | Apoptosis , Histone Demethylase |
SP2509 is a specific histone demethylase LSD1 inhibitor(IC50 =13 nM). | |||
T4527 | Seclidemstat | SP-2577 | Histone Demethylase |
Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM. | |||
T4100 | AS8351 | NSC51355,AS-8351,AS 8351 | Histone Demethylase |
AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblas... | |||
T5368 | Eicosapentaenoic Acid | Histone Demethylase , Others , Endogenous Metabolite | |
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms. | |||
T6593 | ML324 | Histone Demethylase , Others , HSV | |
ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2). | |||
T5825 | Iadademstat dihydrochloride | ORY-1001(trans) | Histone Demethylase |
Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia. |